Alfie passed away at Alder Hey Children's Hospital after he was put on life-support in 2016.
Alfie's parents, Tom and Kate Evans, had been in a constant battle with the courts to overrule and keep their son alive.
Tom Evans said on the social network at around the same time: My gladiator lay down his shield and gained his wings at 02:30 absolutely heartbroken. His Facebook page drew more than 700,000 members.
Kate posted on the Alfies Army page, "Our baby boy grew his wings tonight at 2:30 am".
"Our hearts are broken". Thankyou everyone for all your support.
Dozens of Alfie's supporters gathered at Springfield Park, next door to the Alder Hey Children's Hospital in Liverpool, after the news of his death. "There's only one Alfie Evans".
Balloons released to honour Alfie Evans. Since then, he remained a patient. The decision sparked backlash around the world.
However, judges sided with doctors who said there was no chance of recovery.
The parents' lawyers, from the Christian Legal Centre, had vowed to continue their appeals. "These parents have called him 'their little warrior, ' and for that he surely was".
Although the past few weeks have been hard with much activity on social media, we must recognise that all who have played a part in Alfie's life have wanted to act for his good, as they see it.
"And that was very troubling; it was distressing, and that is something that we have to address in British society", Williams continued. "We could take it further but would that be the right thing to do, would there be more criticism?"
A court ruled on Tuesday that Alfie was too sick to be taken to hospital at the Vatican and nothing had changed since the previous ruling.
Steven Woolfe, Member of the European Parliament, who is pushing to change the law in the United Kingdom "in favour of parents", tweeted, "I am devastated by the passing of little Alfie, who has been a fighter throughout".
Kate and Tom Evans. "Please respect the family's grief and privacy at this time".
After surviving without life support for almost a week, 23-month-old Alfie Evans, who was terminally ill, has sadly passed away, his family announced on social media.
Pope Francis tweeted Saturday that he was "deeply moved" by Alfie's death. "Today I pray especially for his parents, as God the Father receives him in his tender embrace". "We are thinking of you and will always remember your attractive boy Alfie Evans", wrote Brooke Ewing. I can't begin to imagine what his family are going through.
The basic dynamic is like the Gard and Evans and McMath cases but with the generational roles reversed: Instead of parents trying to pry their children away from the medical establishment, you have adult children unable to bring their parents home because their state-appointed guardians say no. You all fought so hard.
Another, Mary Fiander, wrote, "God bless you, handsome Alfie".