The circumstances surrounding each crash vary; in two cases, vehicles appear to have driven around the lowered arm at a train crossing.
The collision occurred in Cayce around 2:45 a.m. Sunday. At least 70 people were reportedly transported to local hospitals in the Lexington County area.
There were eight crew members and approximately 139 passengers on board when an Amtrak train collided with a parked CSX freight train.
Amtrak engineer, Michael Kempf, 54, and conductor Michael Cella, 36, were killed in the incident, reported Margaret Fisher, the Lexington County Coroner.
McMaster said the CSX freight train was stationary on the track when the Amtrack train that was heading south, struck the stationary freight train.
My thoughts and prayers are with all of the victims involved in this mornings train collision in SC. "CSX controls the dispatching of all trains, including directing the signal systems which control the access to sidings and yards", the statement reads. One person on the truck was killed.
Railroad sources familiar with the investigation told NBC News investigators are looking at the possibility that CSX railroad had a switch in the wrong position.
"They paid good money and you got good benefits", he said. You will not be able to see the train.
"The staff members came by and made sure people were okay before we left the auto".
Amtrak CEO Richard Anderson acknowledged the safety concerns Sunday and said he hoped to instill a culture similar to that of airlines: "Amtrak is fully committed and values safety as its highest priority". Amtrak has set up a hotline where family can get information about people involved: 1-800-523-9101. But she says she's never felt unsafe while riding with Amtrak.
CSX issued a statement expressing condolences but said nothing about the cause of the accident. The engineer later told the NTSB he had misread a signal and tried to brake before the accident.
People there are offering comfort and a warm place to stay for the passengers on the train, many of them coming straight from the hospital. The NTSB said it was working to confirm that.
Railroad safety experts have pushed for PTC, and Congress passed a law mandating it in 2008.
Right now all trains must have it by the end of 2018. Today's wreck was the third fatal Amtrak incident since mid-December.
Whitakers police told the station a witness confirmed Dorothy Lyons was driving. Some were limping. Several passengers were still getting out of the train. Both died at the scene.
Amtrak's "Silver Service" is an overnight line that connects NY and Miami with dozens of local stops along the way.