An illness spread through the Tottenham camp prior to the 1-1 draw against Southampton last week, and that has taken a couple of scalps, while Spurs' injury list is getting longer.
Tottenham strolled into the fourth round with a comprehensive 3-0 victory over AFC Wimbledon at Wembley.
When is Newport vs Tottenham and what time is kick-off?
Newport are eighth in League Two and midfielder Paddy Amond is searching for his tenth of the season.
It will mark a momentous occasion for the League Two side as they will be hosting an English top-flight side for the first time in over 30 years and irrespective of the result, the club and the fans will cherish the occasion.
Tottenham boss Mauricio Pochettino has a number of selection decisions to make before the clash at the Newport Stadium. Joss Labadie and Matthew Dolan are not certainties for this tie.
Victor Wanyama, Moussa Sissoko and Erik Lamela should all start for Spurs in the midfield with Fernando Llorente up top.
Even if Harry Kane is given a well-earned rest, the visitors to Rodney Parade should have enough ammunition in their attack to blow the lower-league team away. Kieran Trippier replaces Serge Aurier at right-back while Kyle Walker-Peters comes in for Ben Davies on the left.
No matter, who plays for Tottenham, they should have no trouble against Newport County.
Spurs have scored at least two goals in their last six FA Cup appearances.
Mauricio Pochettino will likely rotate his squad to give his first-team a breather with games against Manchester United, Arsenal, Liverpool and Juventus on the horizon.